Kuldeep Singh Neote

Company: Eli Lilly

Job title: VP, External Innovation

Seminars:

BREAKOUT DISCUSSION GROUPS 12:00 pm

• What are the possible therapeutic approaches of gene therapies for diabetes and how do they compare with cell replacement approaches? • How can we optimize cell therapy efficacy through utilizing gene engineering mechanisms? • How can gene engineering be utilized to reduce alloimmune and autoimmune-mediated rejection of cells? • What is the importance and…Read more

day: Day Three

PANEL DISCUSSION: Advantages or Limitations of Cell and Gene Therapies 11:00 am

• Pros and cons of cells vs gene approaches • Gene transfer methods: non-viral vs. viral • Genetically engineering cells for enhanced efficacy • Cost vs. value of each methodology • What does the manufacturing strategy for these approaches look like?Read more

day: Day Three

BREAKOUT DISCUSSION GROUPS 12:00 pm

• What microstructures provide an immune protective environment to prevent sensitization and rejection? • What is the optimal pore size in membranes required for encapsulation and how does this effect the distance molecule have to travel, selectivity and permeability? • How long will cells survive in an encapsulation device and will the cells have to…Read more

day: Day One

CASE STUDY: Functional Enrichment for Insulin Producing Cells from hPSCs Large Scale Cultures Using Novel Cell Surface Markers Combination 11:00 am

• Using cell-capture antibody array, novel antibodies to distinguish hPSC-derived islets cell populations • Enriching for cells using a novel antibody combination and re-aggregation with MACS technology and large-scale cultures • In vitro and in vivo functional analysis for sorted cells • Strategy development for reducing required cell mass loaded into an encapsulation device to…Read more

day: Day One